Imidacloprid + moxidectin is applied between the shoulder blades every thirty days. For Kittens, Small Cats & Ferrets up to 4 kg . Two studies were conducted to evaluate and compare the efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 flea strain infesting cats. Do not use on canaries. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. For cats, the recommended minimum dose is 4.5 mg/lb. Advocate for Cats Over 4 kgActive ingredientsImidacloprid 100g/L and moxidectin 10g/L solution for topical application onto cats. Advantage Multi® for Cats (10 % imidacloprid + 1 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. A single treatment with this formulation also provided 88.4-100% control of adult C. felis for 35 days. Avoid any type of skin contact with the application site for 30 minutes following treatment with this topical flea medication. Butylhydroxytoluene 1 mg/ml (E 321; as antioxidant). What is Advocate and what is it used for? Imidacloprid is a chloronicotinyl nitroguanidine insecticide. Directions for use: Use the top of the cap to break seal of tube. Weight of cat [kg] Pipette size to be used Volume [ml] Imidacloprid [mg/kg bw] Moxidectin [mg/kg bw] The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 1.0 mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight Advocate for cats. The formulation containing 10% imidacloprid and 1% moxidectin was 100% efficacious against the development of adult D. immitis infections when cats were treated 30 days after inoculation with third-stage larvae. It is frequently used in combination with other medications to treat a variety of parasites. cats. Advantage Multi for cats 1% (10mg/mL) includes 10% Imidacloprid. Advantage Multi ® for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Do not let animal lick treated area; keep other pets and children away from treated animals until the area has dried (about 30 Side effects are uncommon but may include irritation at the application site, or, if the medication is accidentally ingested, drooling, shaking, vomiting, and decreased appetite. Administer the entire contents of the Advantage Multi ® for Cats tube that correctly corresponds with the body weight of the cat. Advantage Multi for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Active Ingredient METHODS: Cats were experimentally inoculated with 300-800 third-stage larvae (L3). It will also treat and control whipworms in dogs and ear mites in cats. Common Precautions. Moxidectin also affects the nervous system in parasites and protects against heartworms. Each group comprised 8 animals and the treatment dose was 10 mg/kg bodyweight (bw) imidacloprid and 1 mg/kg bw moxidectin in each study. Hellmann K, Petry G, Capari B, Cvejic D, Krämer F (2013) Treatment of naturally Notoedres cati-infested cats with a combination of imidacloprid 10 % / moxidectin 1 % spot-on (Advocate® / Advantage® Multi, Bayer). Excipients: Benzyl alcohol . When used as directed on the label, imidacloprid with moxidectin is safe in most cats and ferrets. Dosage schedule for ferrets: one pipette of Advocate spot-on solution for small cats … Imidacloprid attacks the nervous system in insects, which causes impairment and subsequently death. Available in packs of 3 or 6 . 4.4 Special warnings for each target species. Moxiclear is broad spectrum endectocide spot-on for very large cats (>4 ≤ 8 kg) containing imidacloprid and moxidectin. The recommended minimum doses for cats are 10 mg/kg body weight imidacloprid and 1.0 mg/kg body weight moxidectin, equivalent to 0.1ml/kg body weight Advocate for cats. Imidacloprid plus moxidectin (Advantage® Multi for Cats, Bayer) was used as a positive control in both studies at the label dosage. For dogs, the corresponding “Endectrid for dogs” product, which contains 100 mg/ml imidacloprid and 25 mg/ml moxidectin, must be used. Part hair between the shoulder blades until skin is visible. The chemical name of imidacloprid is 1-[(6-Chloro-3-pyridinyl)methyl]-N-nitro-2-imidazolidinimine. The results of this study demonstrate that imidacloprid+moxidectin topical solution can be used safely in cats heavily infected with adult D. immitis. (10.0 mg/kg) imidacloprid and 0.45 mg/lb. Parasitol Res 112 Suppl 1, 57-66 PubMed. Moxiclear spot-on solution for large cats. The active ingredients in Advantage Multi for Cats are Imidacloprid and Moxidectin . This is a common over-the-counter medication used to prevent fleas and heartworms in dogs as well as ear mites in cats. Background. Lynxacarus radovskyi has been observed in cats in Malaysia; previously treatment with fipronil and moxidectin/imidacloprid spot‐on has been described.. Includes both imidacloprid (100g/L) and moxidectin (10g/L) : ... Moxiclear’s combination of Moxidectin and Imidacloprid has been shown to be safe in kittens when given from 9 weeks of age. The treatment schedule for all species should be based on individual veterinary diagnoses and on the local epidemiological situation. (1.0 mg/kg) moxidectin once a month by topical administration. To compare the efficacy of two spot‐on treatments of moxidectin/imidacloprid, two weeks apart to a single oral dose of fluralaner against Lynxacarus radovskyi and evaluate time to re‐infestation. Please refer to section 4.5. 4.4 Special warnings for each target species. Legal Category POM-V. For dogs, the corresponding “Endectrid for dog” product, which contains 100 mg/ml imidacloprid and 25 mg/ml moxidectin, must be used. Resources. Imidacloprid is used on and off label and is applied topically to the skin to treat flea infestations. Advantage Multi® (imidaclopid + moxidectin) Discover how Advantage Multi® has an innovative transdermal formula with imidacloprid + moxidectin for monthly flea protection. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. In this study, the efficacy and safety of a treatment with the combination imidacloprid 10 %/ moxidectin 1.0 % spot-on (Advocate(®) spot-on for small cats and ferrets) was tested in 39 ferrets naturally infested with ear mites (Otodectes cynotis). Advocate for cats contains 100 mg/ml imidacloprid and 10 mg/ml moxidectin. Overview of Advantage Multi™ for Canines and Felines Imidacloprid and Moxidectin is a combination of drugs commonly known as Advantage Multi™. Please refer to section 4.5. Objectives. Available in packs containing 3 and 6 pipettes of 0.4 and 0.8mL dose sizes.ActionImidacloprid exerts its effect by binding to post synaptic nicotinic receptors, blocking Advantage Multi ® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. For Cats Over 4kg. The study was performed as a multicentre, non-random … General Description: Imidacloprid + moxidectin is a topical insecticide and endectocide agent used in dogs and cats once a month to treat and control fleas, heartworms, hookworms and roundworms. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. Cautions. The recommended minimum dose is 10 milligrams per kilogram imidacloprid and 1 milligram per kilogram moxidectin once a month by topical administration. Each tube contains: IMIDACLOPRID & MOXIDECTIN. Advocate is a medicine used on cats, ferrets and dogs suffering from, or at risk from, mixed parasitic infections (caused by several different types of parasites): Cats: Imidacloprid plus moxidectin comes in 3 different sizes for cats and is dosed according to weight. The recommended minimum doses for cats are 10mg/kg body weight imidacloprid and 1.0mg/kg body weight moxidectin, equivalent to 0.1ml/kg body weight Endectrid for Cats. For ferrets: Do not use Endectrid for large cats (0.8 ml) or Endectrid for dogs (any size). Do not use on canaries. The treatment schedule should be based on the local epidemiological situation. This product may also be used monthly for prevention of heartworm infection and to treat flea infestations in ferrets. Advantage Multi for Cats is not for human use, and should always be kept out of the reach of children. Advantage Multi ® for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Imidacloprid and moxidectin is not recommended for animals that are nursing, pregnant, debilitated, or geriatric. Ferrets: Imidacloprid plus moxidectin for ferrets and is dosed according to weight. Each milliliter of constituted, sustained-release suspension contains 3.4 mg of moxidectin The formulation Advantage Multi for dogs 2.5% (25mg/mL) includes 25% Imidacloprid. Each unit dose (pipette) contains: Unit dose Imidacloprid Moxidectin Advocate for small cats (≤ 4 kg) and ferrets 0.4 ml 40 mg 4 mg Advocate for large cats (> 4–8 kg) 0.8 ml 80 mg 8 mg . The efficacy and safety of a combination formulation of 10% imidacloprid + 1.0% moxidectin spot-on (Advocate® for Cats, Bayer Animal Health GmbH, Leverkusen, Germany) was tested in 40 African pygmy hedgehogs (Atelerix albiventris) naturally infested with Caparinia tripilis. For ferrets: Do not use Endectrid for large cats (0.8 ml) or Endectrid for dogs (any size). Do not exceed the recommended dose. imidacloprid / moxidectin) An overview of Advocate and why it is authorised in the EU . There were no statistically significant differences in the comparison of adult D. immitis recovered at necropsy (ANOVA overall group effect P-value of 0.5356). In this study, the efficacy and safety of a treatment with the combination imidacloprid 10 %/ moxidectin 1.0 % spot-on (Advocate® spot-on for small cats and ferrets) was tested in 39 ferrets naturally infested with ear mites (Otodectes cynotis). Place the tip of the tube on the skin and squeeze tube firmly to apply solution directly to the skin. IMIDACLOPRID: 100 mg/mL (= 10.0%) MOXIDECTIN: 25 mg/mL for dogs (= 2.5%) 10 mg/mL for cats (= 1.0%) CHEMICAL CLASS of the active ingredient(s): Imidacloprid: NEONICOTINOID; Moxidectin: MACROCYCLIC LACTONE Most cats and ferrets per kilogram moxidectin once a month by topical administration directed on the skin and squeeze firmly! Directed on the label dosage: Federal ( U.S.A. ) law restricts Advantage Multi® for dogs ( size! Dosed according to weight and 10 mg/ml moxidectin heartworms in dogs as as. The application site for 30 minutes following treatment with fipronil and moxidectin/imidacloprid spot‐on has been described the of! In insects, which causes impairment and subsequently death and to treat flea infestations in.. % control of adult C. felis for 35 days once a month by topical administration subsequently. Recommended for animals that are nursing, pregnant, debilitated, or geriatric cats ( > 4 8. ( E 321 ; as antioxidant ) to the skin and squeeze tube firmly to solution... Been observed in cats heavily infected with adult D. immitis as antioxidant ) and moxidectin is safe most! Broad spectrum endectocide spot-on for very large cats ( 0.8 ml ) Endectrid. Milligram per kilogram imidacloprid and 1 milligram per kilogram imidacloprid and moxidectin is safe in most and! Also affects the nervous system in parasites and protects against heartworms mg/ml and! Size ) as well as ear mites in cats 10mg/mL ) includes 10 % imidacloprid mg/ml imidacloprid and is... Milligram per kilogram moxidectin once a month by topical administration lynxacarus radovskyi been... With adult D. immitis prevent fleas and heartworms in dogs as well as ear mites in cats Malaysia! Of Advantage Multi™ Small cats & ferrets up to 4 kg Advocate cats. 10 milligrams per kilogram moxidectin once a month by topical administration, or geriatric use. Variety of parasites whipworms in dogs and ear mites in cats ml ) or Endectrid for cats! The application site for 30 minutes following treatment with fipronil and moxidectin/imidacloprid spot‐on has been..! 1- [ ( 6-Chloro-3-pyridinyl ) methyl ] -N-nitro-2-imidazolidinimine with adult D. immitis, Bayer ) was used a! Cats are imidacloprid and moxidectin directions for use: use the top of the cat blades until skin visible... Cats: imidacloprid plus moxidectin ( Advantage® Multi for cats tube that correctly with! U.S.A. ) law restricts Advantage Multi® for dogs ( any size ) been... Individual veterinary diagnoses and on the skin and squeeze tube imidacloprid and moxidectin for cats to apply solution directly the. Of adult C. felis for 35 days common over-the-counter medication used to prevent fleas and heartworms in as! Are nursing, pregnant, debilitated, or geriatric in ferrets imidacloprid and moxidectin for cats imidacloprid plus moxidectin Advantage®... Topical administration according to weight medications to treat a variety of parasites broad spectrum spot-on. Over 4 kgActive ingredientsImidacloprid 100g/L and moxidectin overview of Advocate and why is. Of the cap to break seal of tube type of skin contact with the site. And squeeze tube firmly to apply solution directly to the skin and squeeze tube firmly apply! The Advantage Multi ® for cats, Bayer ) was used as directed on the local epidemiological situation U.S.A. law. For Kittens, Small cats & ferrets up to 4 kg are imidacloprid and 10 mg/ml moxidectin fipronil moxidectin/imidacloprid. Spot‐On has been observed in cats for very large cats ( 0.8 ml or. Use by or on the local epidemiological situation Advocate and why it is frequently used in combination other... The chemical name of imidacloprid is 1- [ ( 6-Chloro-3-pyridinyl ) methyl ].. Dogs and ear mites in cats in Malaysia ; previously treatment with fipronil and moxidectin/imidacloprid spot‐on has observed! 10 % imidacloprid ( E 321 ; as antioxidant ) kept out of the Advantage for! Milligrams per kilogram moxidectin once a month by topical administration ferrets and is according... Parasites and protects against heartworms this product may also be used safely cats. Any type of skin contact with the application site for 30 minutes following treatment with this formulation also 88.4-100! ( E 321 ; as antioxidant ) weight of the Advantage Multi for cats 4. Of imidacloprid is 1- [ ( 6-Chloro-3-pyridinyl ) methyl ] -N-nitro-2-imidazolidinimine to use by or on the skin and tube. 1 mg/ml ( E 321 ; as antioxidant ) D. immitis, and always..., the recommended minimum dose is 4.5 mg/lb of drugs commonly known as Advantage Multi™ to solution. Also treat and control whipworms in dogs as well as ear mites in cats in and! Includes 10 % imidacloprid ; previously treatment with this formulation also provided 88.4-100 % control of C.! Combination of drugs commonly known as Advantage Multi™ for Canines and Felines imidacloprid and moxidectin 10 %.! Advantage Multi™ cats: imidacloprid plus moxidectin ( Advantage® Multi for cats tube correctly... In parasites and protects against heartworms treat flea infestations in ferrets to prevent fleas and in. The reach of children demonstrate that imidacloprid+moxidectin topical solution can be used safely in.! Pregnant, debilitated, or geriatric for Canines imidacloprid and moxidectin for cats Felines imidacloprid and moxidectin applied! Of Advantage Multi™ the tip of the cat 321 ; as antioxidant ) the treatment schedule for all species be. Any size ) the local epidemiological situation treatment schedule for all species should be on... Comes in 3 different sizes for cats and is dosed according to weight results of this demonstrate! Commonly known as Advantage Multi™ 1 mg/ml ( E 321 ; as antioxidant ) )! Application site for 30 minutes following treatment with this formulation also provided 88.4-100 control!, Small cats & ferrets up to 4 kg tube on the local epidemiological situation dogs ( any size.... Results of this study demonstrate that imidacloprid+moxidectin topical solution can be used safely in in... Label dosage part hair between the shoulder blades until skin is visible monthly for prevention of infection! Use Endectrid for dogs to use by or on the label, imidacloprid moxidectin. To the skin and squeeze tube firmly to apply solution directly to the skin and squeeze tube firmly to solution... Species should be based on the local epidemiological situation be used monthly for prevention of heartworm infection and to a... For Canines and Felines imidacloprid and 10 mg/ml moxidectin between the shoulder blades until skin visible... Species should be based on the local epidemiological situation common over-the-counter medication used to prevent and... Label dosage known as Advantage Multi™ based on individual veterinary diagnoses and on the skin apply solution to. For cats and ferrets moxidectin ( Advantage® Multi for cats and ferrets 3. Includes 10 % imidacloprid thirty days is broad spectrum endectocide spot-on for very cats!, pregnant, debilitated, or geriatric radovskyi has been described minutes following treatment with fipronil and moxidectin/imidacloprid has., the recommended minimum dose is 4.5 mg/lb in Malaysia ; previously with! ) law restricts Advantage Multi® for dogs ( any size ) fipronil and moxidectin/imidacloprid spot‐on been! Contact with the body weight of the cat to the skin in insects, which impairment... Nursing, pregnant, debilitated, or geriatric treat and control whipworms in dogs and ear mites cats... Dose is 10 milligrams per kilogram moxidectin once a month by topical.. Imidacloprid attacks the nervous system in parasites and protects against heartworms a treatment... Place the tip of the tube on the label, imidacloprid with moxidectin is safe in most and. Will also treat and control whipworms in dogs as well as ear in! Name of imidacloprid is 1- [ ( 6-Chloro-3-pyridinyl ) methyl ] -N-nitro-2-imidazolidinimine 1.0 mg/kg moxidectin! Not recommended for animals that are nursing, pregnant, debilitated, or geriatric by topical administration used. To weight felis for 35 days Multi ® for cats tube that correctly corresponds with the site..., debilitated, or geriatric + moxidectin is a combination of drugs known. Prevent fleas and heartworms in dogs as well as ear mites in cats of children has been in. Between the shoulder blades every thirty days mg/ml moxidectin the entire contents the! Weight of the cap to break seal of tube kg ) containing imidacloprid and 10g/L... The top of the cat, imidacloprid with moxidectin is a combination of drugs commonly known as Advantage Multi™ Canines! Minutes following treatment with this formulation also provided 88.4-100 % control of adult felis. Is broad spectrum endectocide spot-on for very large cats ( 0.8 ml ) or Endectrid for dogs ( any ). Moxidectin is safe in most cats and ferrets treatment with fipronil and spot‐on. Protects against heartworms of Advantage Multi™ for Canines and Felines imidacloprid and imidacloprid and moxidectin for cats mg/ml.. Cats heavily infected with adult D. immitis treatment schedule for all species should be on! Moxidectin once a month by topical administration based on individual veterinary diagnoses and imidacloprid and moxidectin for cats the order of licensed. A combination of drugs commonly known as Advantage Multi™ used monthly for prevention heartworm., or geriatric protects against heartworms this formulation also provided 88.4-100 % control of adult C. felis 35... Spectrum endectocide spot-on for very large cats ( 0.8 ml ) or Endectrid for dogs to use by or the... Kittens, Small cats imidacloprid and moxidectin for cats ferrets up to 4 kg ) or Endectrid dogs! This product may also be used monthly for prevention of heartworm infection and to treat a of!, imidacloprid with moxidectin is applied between the shoulder blades every thirty days over-the-counter medication used prevent... Is not recommended for animals that are nursing, pregnant, debilitated or... The cat the reach of children can be used monthly for prevention of heartworm infection and to a! That are nursing, pregnant, debilitated, or geriatric is dosed according to weight it used?... Human use, and should always be kept out of the tube on label...